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2011/06/24 15:03:43 |
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來自 新北市
磅數 12.4磅
發文 7
註冊 2009/8/8 上
量級 蠅量級
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在PO一篇關於類固副作用與肝損傷的文章
原文底下附上大概的翻譯
翻不好還請見諒
Liver damage is probably the most sensationalized of all side effects possible from steroid use. The media often focuses on this particular problem as if it occurs with every steroid, and in every person who takes them. Nothing could be further than the truth. Most anabolic steroids which are ingested orally pass through the liver, which functions as the body´s filtration system. When something goes through the liver, it is broken down by various enzymes, and passed along into the bloodstream. Most research on orally administered anabolic steroids focus on the fact that liver enzymes are elevated following ingestion. But does this necessarily mean that the liver is being damaged, does it? Of course not. Commonly, studies that focus on steroid toxicity often use absurd doses, or incorrectly focus on liver activity instead of damage. The liver functions as the filter for the human body.. it´s going to be activated whenever something (not just a steroid) passes through it. Does that show that steroids damage the liver? Let´s see what the scientists say..
There was an eight-week study done in 1999, which looked at the effects of an 8-week cycle of Oral steroids. The steroids examined were Halotestin (Fluoxymesterone), Dianabol (methylandrostanolone), or Winstrol (Stanozolol) on rats at the dose of 2mg/kg-body weight, administered five times a week for 8 weeks. That s almost 200mgs/day of any of those steroids, for a 200lb user. That is, I´ll speculate, much more than the average person would use on a cycle. In fact, I have never, in my years of researching steroids and speaking with athletes, heard of anybody using 200mgs/day of Halotestin, Winstrol, or Dianabol. Ever.
And, at the end of that study, In vivo, each rat still had liver enzyme levels that were within normal range!
(*Med Sci Sports Exerc. 1999 Feb;31(2):243-50, Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Molano F, Saborido A, Delgado J, Moran M, Megias A.)
In another study, 16 bodybuilders using steroids were compared to 12 bodybuilders who were not. Then the bodybuilders who had used steroids stopped taking them for three months, at which points, the researchers found that liver enzymes had returned to the same levels as the non users. After only 3 months!
(*Int J Sports Med 1996 Aug;17(6):429-33, Body composition, cardiovascular risk factors and liver function in long-term androgenic-anabolic steroids using bodybuilders three months after drug withdrawal. Hartgens F, Kuipers H, Wijnen JA, Keizer HA.)
We can see from the chart below that ex-steroid users have totally normal liver enzymes one year after they stop using& .in fact, for some liver enzymes, even the current users have normal scores!
肝臟的損傷應該是使用類固醇中最常被人拿來炒作的話題。媒體也只專注在這話題上，
彷彿所有使用類固醇的人、與類固醇本身都會造成肝臟的傷害。但是實際情況是大多
數的口服類固醇都必須要經過肝臟，因為肝臟就像是身體的過濾系統，當有東西經過
肝臟時，這些物質會被肝臟中的酵素分解，然後藉由血液傳輸。可是大部分對於口服
類固醇研究著重在攝取之後使肝臟中分泌的酵素提升，但是這代表著肝臟受到傷害了嗎?
當然不是，通常這些專注在類固醇毒性上的研究都使用了荒謬的劑量或者是錯誤的專注
在肝臟的活動(這裡的活動應該指的就是肝臟在分解口服類固醇的過程讓肝臟指數異常升高)而非傷害。肝臟
的功能本來就是用來過濾，不管是甚麼東西，不只是類固醇而已，難道這樣就代表著對
肝臟的傷害嗎?來看看科學家們怎麼說
這是一個在1999年所做的八周實驗計畫，實驗的內容在於研究八周的口服類固醇對於實
驗鼠所產身的副作用。實驗用的口服類固醇有， Halotestin (Fluoxymesterone),
Dianabol (methylandrostanolone), or Winstrol (Stanozolol)，而使用在實驗鼠的
劑量則是每一種藥劑每公斤體重2mg的劑量，經由一周五次的監測連續實行八周，這樣
子的劑量相當於一個200lb的使用者一天使用200mg的劑量(三種藥物中的任何一種)。
這樣子的劑量是遠超過任何人或者是任何cycle會用的量，事實上在我所認識的運動員
包括我自己也從來沒有聽說過有任何人會使用這三種藥劑一天200mg的劑量。
然後在這個實驗結束時，這些實驗活鼠體內的肝臟酵素依然保持著正常值
我們可以看到底下的圖表這些曾經使用類固醇的人在他們停用一年後的肝臟指數是完全
正常的，事實上有些人甚至在使用類固醇的當下一樣能保持肝臟指數的正常值。
※本文於2011/6/24 下午 03:13:25修改※
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